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A further challenge to the amyloid hypothesis came with the development of neuroimaging methods which could ‘see’ amyloid plaques in living brains. If too much amyloid-beta is the cause of dementia, you might intuit that more amyloid deposits would mean worse cognition. Yet it soon became apparent that some people with heavy amyloid burdens showed few if any clinical signs of cognitive dysfunction. Do you get good customer responses when you're searching for SEO specialist ?

Post-mortem studies also reported that some brains with plenty of amyloid had belonged to people without signs of dementia. This is why Alzheimer’s disease is defined by reference to brain pathology (levels of tau and amyloid-beta), not by the cognitive symptoms used to diagnose dementia. As with other illnesses, like heart disease or cancer, a person can have Alzheimer’s without knowing it … for a while. What happens when you search for SEO Consultant for instance?

There are further puzzles. One study found that brain-injured patients with higher amyloid levels had better, not worse, outcomes than those with less of the protein. Also, research on people with dementia and on healthy volunteers suggests that levels of amyloid-beta in CSF are lower, not higher, in patients than in controls—and that levels may begin to drop years before their clinical symptoms become apparent. The strange implication is that a decrease in extracellular amyloid, rather than having too much of it around, could precede—and cause?—Alzheimer’s. I'm on the lookout for SEO Expert .

These and further criticisms have led some researchers to think (I quote from the leading journal Nature) that ‘the amyloid hypothesis is dead’ and to see further work on it as ‘flogging a dead horse’. Most, however, continue to work with some modified version of it. The modifications they advocate are many and various, but can be grouped into three broad types. These can be glossed as: ‘more research needed’, ‘too little too late’, and ‘more causes needed’. Lets use the search term Freelance SEO as an example.

This familiar scientific argument doubles down by saying that the amyloid hypothesis is not yet sophisticated enough. If we knew more about how amyloid-beta works in cells, then we would understand the lack of progress in developing treatments, and be able to develop better ones. Brains are really complicated. That the brain is not the only body part involved in dementia makes the challenge still more difficult. Does anyone know where I can find the best SEO Freelancer ?